Ageing Gracefully With NAD



NAD stands for nicotinamide adenine dinucleotide, a molecule that controls the body’s response to stress. It regulates practically every metabolic activity, from energy metabolism to cell survival. NAD levels decline with age, leading to altered metabolism and increased susceptibility to disease in older people. One of its most important roles is strengthening and protecting mitochondria, the energy storehouses of cells. Restoring NAD levels in older animals both promoted good health and extended lifespan. The discovery has stimulated a search for effective ways of keeping NAD levels in the optimal range in humans throughout life, including using artificially synthesized molecules, thereby increasing disease resistance and extending healthy human lifespan. Movingcompaniesmiamif

NAD can exist in two forms, the oxidized NAD+ and reduced NADH. The term ‘NAD’ is used to refer to either form. NAD is a crucial requirement for the function of satins, a family of proteins that chemically modify other proteins in order to control critical cellular processes, including energy metabolism, inflammation, cell growth and stress resistance.

Boosting NAD levels prevented and reversed cancer in animal studies. After partial liver removal, mice treated with an NAD booster recovered much faster, and maintained healthier livers, than mice not so treated. NAD supplementation also protected against kidney damage caused by high glucose levels. Treatment with NAD reversed age-related muscle damage and prevented nerve cell damage. Other experiments have shown that NAD improves heart function, restores normal glucose levels, prevents obesity and treats alcoholic steatitis successfully. In experiments on aged animals, supplemental NAD increased activity, improved insulin sensitivity and lipid profiles, improved vision and restored bone density to levels normally found in younger animals. Movingcompaniesmiamif

The results of initial trials in animals suggest that boosting NAD levels in humans may be good therapy against age-associated diseases, and may perhaps even delay ageing. However, most of the experiments were conducted in animals, and several lines of scientific evidence demonstrate that critical physiological and genetic peculiarities of different species often invalidate the use of animals to study human diseases or treatments. According to the FDA, 92% of drugs that pass preclinical tests fail to proceed to the market. More recent analysis indicates that the failure rate for predicting animal testing results has increased to almost 96%. With respect to NAD supplementation, studies have shown that the metabolic pathway linked to slower ageing through NAD boosting also fuels brain cancer. Meanwhile, the results of the mainly animal-based studies have precipitated a surge of interest from the $123 billion supplementation industry, and the supplement market has been overwhelmed with vendors, of variable integrity. Caution is therefore recommended in approaching the use of NAD supplements for nutritional therapy.


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